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In contrast, in IFN-γR −/− mice cuprizone-induced microglia accumulation was initially diminished or simply delayed (Mana et al., 2006) that was reflected at week 3 of cuprizone diet by a reduced expression of microglia-associated molecules such as IGF-1 and TNF-α that have been proposed to promote proliferation of OPC

Fine Lines & Wrinkles

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