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Zepbound Side Effects Common Zepbound Side Effects The most common Zepbound side effects include: Feeling sick, nausea 25% Diarrhea 19% Constipation 17% Indigestion, dyspepsia 9% Abdominal pain 9% Vomiting 8% Injection reactions 6% Tiredness, fatigue 5% Hypersensitivity reactions 5% Hair loss 5% These common side effects occurred in 5% or more of patients taking Zepbound 5mg in Zepbound clinical trials SURMOUNT-1 (NCT04184622) and SURMOUNT-2 (NCT04657003), two randomized, double-blind, placebo-controlled trials