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Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses - Journal of Lipid Research
The extruded disc material can be cleared away by macrophage (an immune cell that mops up debris) activity over months
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Additionally, promoting the differentiation of macrophages toward the M2 phenotype is another beneficial anti-inflammatory action since M2 macrophages are generally associated with tissue repair and wound healing (Ortiz et al., 2020)
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