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Establishing the cause of the raised cortisol A variety of tests are used to determine whether the cortisol excess is caused by: Over-production by the adrenal gland (ACTH-independent Cushing's) Over-stimulation of the adrenal gland by pituitary ACTH (ACTH-dependent Cushing's) Over-stimulation of the adrenal gland by ectopic ACTH (ACTH-dependent Cushing's) These are summarised in the algorithm below (Fig

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Some studies show modest increases in blood glutathione stores with consistent daily dosing, while other trials found no significant change, highlighting how inconsistent the evidence remains