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Special emphasis should be placed on elucidating the dual regulatory mechanisms of ammonia metabolism in CAR-T therapy: maintaining appropriate ammonia levels in the early phase to activate RUNX2-mediated T-cell function, while reducing lysosomal pH via agents such as C381 in the later phase to delay T-cell exhaustion (172)
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Increasing the speed and accuracy with which repair cells navigate to injury sites can significantly accelerate overall healing timelines
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