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In U87 and SF295 glioma cells with BTN3A2 knockdown, the phosphorylation levels of ATM, ATR, CHK1, CHK2, and H2AX (p-ATM, p-ATR, p-CHK1, p-CHK2, γH2AX, respectively) were elevated following TMZ treatment and persisted for a minimum of 24 hours (Fig
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In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes
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