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Similarly, apigenin potentiates neurite outgrowth in cultured neurons by augmenting TrkB/BDNF expression in response to Aβ25-35-induced cellular stress in SH-SY5Y cells and rat cortical neurons ( 5 Phytocompounds with neurogenic and plasticity-enhancing effects: clinical translation The Clinical Translation section offers a critical evaluation of human evidence linking the neurogenesis and neuroplasticity effects of natural products observed in preclinical studies with clinical results in AD and mild cognitive impairment (MCI) (Figure 3) ( FIGURE 3 The process of developing AD therapies through natural products requires scientists to validate human evidence, since biological plausibility has consistently failed to yield effective clinical solutions