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Signal initiation, propagation and termination processes are linked by a common cellular machinery involving GPCRs, the heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs), β-arrestins, and a host of proteins that are recruited from the endocytic and ubiquitination pathways

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Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Olliaro and Mussano, 2003