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Recently, manganese-based superoxide dismutase like synthetic AO synzyme (M40403), and azymes[9] have also been added to synthetic AOs group of N-acetylcysteine, pencillinamine and tetracyclines.[4] Oxidative stress (OS) leads to molecular damage resulting from disturbances in redox signaling and control due to an imbalance between oxidants and AOs oxidants ROS.[10,11,12] OS is considered to play an important role in the pathogenesis of chronic inflammatory conditions like non-insulin dependent diabetes mellitus, cardiovascular disease, metabolic syndrome,[11,13,14,15] acute respiratory distress syndrome,[5,16] and periodontal disease.[5,17,18,19,20,21,22] Recently, it has been proposed as a central link between systemic diseases and periodontitis.[23] Ubiquitous AO master, glutathione is a low-molecular weight, major non-protein cellular thiol, present in both eukaryotic as well as prokaryotic cells,[24,25,26] and exist in every single cell of the human body.[24] It is a potent AO that prevents ROS mediated damage to essential cellular components and acts as a cofactor for enzymes in the destruction of ROS