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In contrast, both the NMDAR subunit NR2A and glutamate aspartate transporter (GLAST) – two factors that counteract excitotoxicity – are upregulated in the corpus callosum of cuprizone-fed mice after 5 weeks [144]

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Finally, given the recent release of updated blood pressure guidelines, a commenter noted that CMS may have to modify this measure in the near future to reduce the current target blood pressure range which may result in limited comparability of results over the 5-year proposed timeframe