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HGF and VEGF play a synergistic effect in promoting endothelial cell survival by enhancing the anti-apoptotic genes Bcl-2 and A1 (Xin et al., 2001)
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[27] Additionally, anyone with Leber’s hereditary optic neuropathy (a rare inherited eye disease) must avoid cyanocobalamin injections, since B₁₂ can precipitate rapid worsening of that condition
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