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The decreased availability and utilization of glucose leads to the development of a hypometabolic state characterized by a condition of energy crisis within the brain that may progress to atrophy of major areas and neuronal and synaptic disconnection (388, 389)

Vitamin B Complex

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In an effort to identify the cellular substrate underlying the rapid antidepressant effects of ketamine and GluN2B-selective antagonists, this work demonstrates that activation of the mammalian target of rapamycin (mTOR) pathway and the subsequent increase in new synapses are likely to be relevant events