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Targeted prevention of radiation-induced oral mucositis by glutathione-modified liposome coated K12 probiotics and clinical study - ScienceDirect
Indole-3-acetic acid (I3A), a gut-microbiota-derived metabolite from dietary tryptophan, can improve oxidative stress and hepatic steatosis by increasing mitochondrial oxidative phosphorylation in a PPARγ-coactivator-1α-dependent manner [177]
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In addition, cotreatment of docetaxel-resistant NSCLC with docetaxel plus R162 inhibited cancer cell growth and metastasis both in vitro and in xenograft mouse models, again suggesting that combination therapy with anticancer drugs plus a GLUD1 inhibitor is an effective cancer treatment 23
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