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Histamine intolerance (HIT) is a proposed condition caused by an inability to digest histamine in your diet, leading to gastrointestinal and allergy-like symptoms

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This is a very important and possibly crucial biochemical mechanism, since reversible thiolation of proteins can modify their enzymatic activities (glycolytic enzymes, components of the respiratory chain, creatine kinase, carbonic anhydrase), ion and metabolite transport, gene transcription, signal transduction and cell death