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Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand
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Several candidate non-glutathione disulfide substrates for the dithiol mechanism have been identified using monothiol glutaredoxin mutants as bait proteins for the trapping of Grx(SSR) species (Fig
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