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163 Taken together, the available evidence suggests that methotrexate treatment in rheumatoid arthritis is associated with a reduced risk of type 1 and type 2 diabetes, although the mechanisms underpinning the effects on glucose metabolism require further studies (Figure 3)

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We will then set out the physicochemical properties of biological signals and sensor proteins that allow them to act as specific sensor/signal pairs in the backdrop of the cellular milieu

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