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These include dominant mutations, unintended effects on neighbouring genes, risk of insertional mutagenesis, the size limitation of viral vectors and low efficacy of removing targeted genetic material [195]

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*Correspondence: Jingmin Liu, [email protected] Yu, [email protected] †These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers