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GzmB, a caspase-like serine protease, triggers apoptosis of virus-infected cells or tumor cells by activating caspases-3 and -8 ( It has been established that Sb9 can protect tumor cells from GzmB mediated destruction, whether GzmB originates from cytotoxic lymphocytes or is produced endogenously ( regs ] and myeloid-derived suppressor cells [MDSCs]) ( It’s worth noting that apart from its role in regulating GzmB, human Sb9 can also influence cytokine production by modulating inflammatory caspase-1, and to a lesser extent caspase-4 and caspase-8, but not caspase-3 (35, 36)