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Glutathione supplementation, but not Nrf2 inhibition, restores... | Download Scientific Diagram
The treatment normalized serum corticosterone levels, enhanced central GABA and serotonin concentrations and reduced peripheral inflammation and gut microbiota profiling revealed a reduction in potentially pathogenic genera ( Acinetobacter, Enterococcus, Bacillus ) and increased abundance of beneficial taxa ( Muribaculum, Alistipes, Lactobacillus ), indicating the therapeutic potential of targeted psychobiotic intervention for stress-related disorders (Tyagi et al., 2025)
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These isoforms also display differential substrate preferences: PHD-2 mainly hydroxylates HIF-1α under normoxia, while PHD-3 becomes the dominant regulator of HIF-2α stability under prolonged hypoxic conditions [72]
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