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mTORC1 can simultaneously activate SREBPs, transcription factor ATF4, HIF1, Yin Yang 1 (YY1), PPARy, and PGC1a to drive mitochondrial regulation, ATP regulation, macromolecule synthesis, and cellular growth, blocking lysosomal biogenesis through transcription factor EB (TFEB) (Liu and Sabatini, 2020b
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