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It should be mentioned that TCM, especially formulas, have multiple ingredients/components, exerting multiple effects against UC, such as immune modulation, gut microbiota hemostasis maintenance, protection of intestinal barrier integrity (tight junctions), etc
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Interestingly, murine studies have shown that intestinal overexpression of ACE2 is associated with increased abundance of anti-inflammatory microbial species, in contrast to ACE2 knockout models, which exhibit more proinflammatory profiles [86]
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