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231,232 Additionally, PD-1 serves as a marker of exhausted T cells (Tex cells), and inhibiting PD-1 can reactivate these “dysfunctional” CD8⁺ Tex cells
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The pathway requires reduced glutathione (GSH) as a co-substrate and converts MeGx into D-lactate (D-Lac) (as opposed to the L-lactate produced by glycolysis in higher organisms 16 ), which is then further metabolized in peroxisomes 17
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