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Polyunsaturated fatty acid phospholipid hydroperoxide (PUFA-PL-OOH) is the key effector in this process, produced through the combined action of Fe2+, lipoxygenases (arachidonate lipoxygenases), phosphatidylethanolamine-binding protein 1 complexes, cytochrome P450 reductase and ROS
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In human red blood cells, the src kinase hck was activated by peroxynitrite via cysteine oxidation, whereas another src kinase, lyn , was activated through a mechanism involving the inhibition of Tyr527 binding to the SH2 domain (838, 840)
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