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SG has also been analyzed in 62 patients with refractory SCLC included in the IMMU-132-01 phase I-II trial, showing an ORR of 17.7%, a median PFS of 3.7 months and a median OS of 7.1 months [48,92]
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The rate depends strongly on pH and temperature, with the acid-catalyzed and base-catalyzed routes having different products and different neighboring-residue dependencies
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