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In support of this, we prepared primary cultures of cerebellar granule cells from Bdnf-Luc mice using a 96-well culture plate, and found that membrane depolarization increased luciferase activity, which agreed with previous reports regarding the activity-dependent Bdnf expression in cultured cerebellar granule cells 32,33
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295 Targeting Notch signaling represents a potential therapeutic avenue, particularly in combination with hypoxia or angiogenesis inhibitors
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