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This process is closely linked to imbalances between oxidative and antioxidant systems, with homeostatic maintenance being essential for cellular integrity ( 3.2.2 Relationship between lipid peroxidation and ferroptosis Lipid peroxidation manifests as a continuous process of free radical production and reaction—a chain reaction that severely compromises cell membrane integrity, ultimately leading to organelle and/or cell membrane rupture ( Bioinformatic analyses of CHD-related datasets have identified differentially expressed genes (DEGs) associated with immune and inflammatory responses