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2011) High potency in the animal model — the procognitive effect was reported at working concentrations on the order of nanograms per kilogram of body weight in rodents, which was described as one of the highest potency profiles in the class of studied prosynaptic compounds Pharmacokinetic profile (based on preclinical models): Oral bioavailability in humans: unknown (data limited to animal models) Blood–brain barrier penetration in humans: uncharacterized Human PK profile: uncharacterized — no phase I studies Molecular target: augmentation of the HGF/c-Met axis