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Persistent viral infections and prolonged antigen exposure eventually cause T cell exhaustion, leading to vulnerability to opportunistic pathogens, such as pneumonia or skin infections, in the case of HIV.[ref][ref] Persistent stimulation: T cell exhaustion occurs with chronic antigen stimulation, which can be caused by: Persistent, active infections, including hepatitis C, hepatitis B, HIV, tuberculosis, malaria, some long Covid[ref] Certain types of cancer or immunotherapy Repeated Covid mRNA vaccination[ref][ref][ref] Initial stages of some autoimmune diseases[ref] Checkpoints upregulated to put the brakes on: After chronic activation, the CD8+ T cells eventually move into an altered state, with a sustained upregulation of inhibitory checkpoint receptors, such as PD-1, TIM3, CTLA-4, and LAG-3, that put the brakes on the T cells’ activity (more details below)

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Consultar con un especialista si se está en tratamiento con medicamentos anticoagulantes, hipolipemiantes o antihipertensivos