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This neuroendocrine activation profoundly affects gastrointestinal motility and secretory functions, subsequently shifting the microbiome composition (Singh et al., 2016
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Despite there is no consensus on regarding the features a binding site must have to be druggable, some authors may argue that features like hydrophobicity, shape, size, or even the combination of them are pivotal to make a site druggable 101,102,103
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