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Particularly preferred is the combination of C-l Antitumor Agent, or a pharmaceutically acceptable salt thereof, with sirolimus, temsirolimus, everolimus, ridaforolimus, KU-0063794 and WYE-354, and even more preferred is the combination with temsirolimus in the treatment of lung cancer, sarcoma, malignant melanoma, prostate cancer, pancreas carcinoma, gastric carcinoma, ovarian cancer, breast cancer, colorectal cancer and brain cancer

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For context, the fat-mass reductions reported in Billon 2024 — roughly 25-30% in diet-induced obese mice over 28 days without exercise — are large for a preclinical metabolic agent and explain why the "exercise mimetic" label stuck