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Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy - PMC

To generate rod-specific conditional IGF-1R KO mice, we mated homozygous floxed IGF-1R mice with mice expressing Cre-recombinase under the control of rhodopsin promoter (i75-Cre) [26]

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These studies show that the oral administration of 6-9 mg melatonin at bed time significantly retards the progression of the disease, reduces symptoms such as sundowning and modifies the sleep pattern of the patients [3, 6, 7, 16, 36]