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Despite the fact that absent or low NQO1 activity has been associated with susceptibility to cancers (the role as cell protector), a marked up-regulation of NQO1 has been found in many inflammatory conditions and tumorous tissues [12]
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44 NADPH oxidase (NOX) is a key enzyme that oxidizes NADPH to generate ROS through the ubiquitin-proteasome system, which contributes to lipid peroxidation and cell membrane damage, ultimately leading to ferroptosis
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