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In this position, ONBY sits in the intramolecular indole channel in the protein complex through which indole is passed from TrpA to TrpB, where it orients in a pinwheel arrangement with Y279 and F280 in TrpB, two residues that serve as gating residues for the channel (Figure 22C)

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FIGURE 2 2.3 Autophagy Autophagy is a bioregulatory process that can recognize and degrade damaged macromolecular proteins, organelles, and invading pathogens for cellular recycling to maintain cellular homeostasis ( Furthermore, epidermal growth factor receptor (EGFR) is widely expressed in mammalian kidney podocytes ( A multitude of studies have demonstrated that proximal tubular epithelial cells (PTEC) play a pivotal role in maintaining normal kidney function and tissue repair