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Emerging evidence now links dysregulated mTOR signaling and impaired autophagy to G2/M arrest in aged tubular cells, exacerbating senescence and fibrosis (O'Sullivan et al., 2022)

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2009, titled “The structure and function of G-protein-coupled receptors.” These receptors—primarily the mu, delta, and kappa receptors—are part of the body’s natural pain control system and regulate the perception of pain, mood, and even gastrointestinal function