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6 Aripiprazole exhibits high affinity for dopamine D 2 and D 3 , and serotonin 5-HT 1A and 5-HT 2A receptors (K i values, 0.34 nM, 0.8 nM, 1.7 nM, and 3.4 nM, respectively)

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The rationale for combining these peptides in preclinical models rests on their distinct receptor targets