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These injections are painless for most patients, with others only reporting a small pinch, and can be administered in the morning or evening, depending on individual circumstances and goals
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Several studies have shown that GHSR antagonists improve glucose tolerance associated with obesity by enhancing insulin secretion [261,287], and it was more recently demonstrated that ghrelin inhibition with the GHSR antagonist GHRP-6 could reverse diabetic symptoms also in a genetic mouse model of maturity-onset diabetes of the young, type 3 (MODY3) caused by mutations of the HNF1-alpha homeobox gene [288]
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