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In this model, cells are incubated in a glucose-free medium under deoxygenated atmosphere in order to mimic the conditions occurring during an ischemic stroke (Tasca et al., 2015)
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Furthermore, we used 750 mg/kg APAP to challenge the mice and determine the survival rate, the results showed that Sirt6-Tg also improved survival of mice within 54 h (Fig
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