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gingivalis induced death of silk-worms.[80] Further, the stress-inducible protein heme oxygenase-1 expressed in human gingival fibroblasts exposed to nicotine has been reported to be overcome by the addition of the glutathione precursor N-acetyl-L-cysteine.[49,88] Minor antioxidative effects have been documented after the application of exogenous glutathione and cysteine, however, whether exogenously applied substances elevated the intracellular glutathione concentrations, still need to be investigated.[135] Improvement in the rate of wound healing has been observed with topical NO donor, GSNO