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This leakage further activates microglia towards the M1 phenotype, promoting release of neurotoxic agents, including TNF-α and IL-6 (50)
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Объем:35 мл
Several studies suggest that the primum movens for CD onset depends on an increased intestinal permeability, which leads to gluten passage from the lumen to the mucosal layer and innate cytotoxic immune activation on epithelial cells further enhancing gluten migration (249)
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