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Mutations in IDH1/IDH2 produce 2-HG instead of normal α-KG, an oncogenic metabolite that inhibits many α-KG-dependent enzymes, thereby affecting DNA and histone methylation and nucleic acid metabolism

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The researchers found a U-shaped association using geographic detectors and restricted cubic spline curves, showing that higher male infertility ASPR is linked to both high and low ambient temperatures with the lowest prevalence noted at 16 °C (128)