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The oncogenic impact of MDH2 is amplified by its suppression of the repair enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH), whose activity is reduced by up to 50% under hypoxic conditions, particularly in mitochondria

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155:830–843 10.1016/j.cell.2013.09.056 [DOI] [PubMed] [Google Scholar] Minogue S., Waugh M.G., De Matteis M.A., Stephens D.J., Berditchevski F., Hsuan J.J