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Further to the recently reported cryogenic electron microscopy (cryo-EM) structures of VIP1R and PAC1R 13,14,15,16 , here we determine two single-particle cryo-EM structures of the human VIP2R in complex with PACAP27 and the stimulatory G protein (G s ), at global resolutions of 3.4 and 2.7 Å, respectively
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