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Mature mast cells are present in the areolar connective tissue space of many organs, such as the adventitial layer of blood vessels, skin, nerve fibers, smooth muscles, airways, gastrointestinal tract, and adipose tissue (14–16)

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Solving the resulting first order ordinary differential equation then yields the following expression for 6′-OH CZX formation versus time (using notation [P](t) to denote concentration at time t (min)): [P](t) = [S](0)(1 − exp(−αt/V)), where [S](0) = initial CZX concentration (1 uM) and V is the sample volume (0.02 ml)

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