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Trial data at a glance Zepbound / tirzepatide (SURMOUNT-1, 72 weeks, adults without diabetes): Average weight loss at 15 mg: 22.5% 91% lost ≥5% of body weight 49% lost ≥20% Ozempic / semaglutide (off-label, based on STEP 1 and SUSTAIN data): At 2.0 mg (max dose): approximately 12–14% weight loss At 0.5–1.0 mg (typical diabetes doses): 4–7% weight loss Note: Ozempic’s weight loss data comes from diabetes trials, not obesity trials SURMOUNT-5 — the only head-to-head trial (72 weeks): Tirzepatide vs semaglutide 2.4 mg (Wegovy dose, not standard Ozempic) Tirzepatide: 20.2% average weight loss Semaglutide: 13.7% average weight loss Gap: 6.5 percentage points — statistically significant Figure 1