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For example, the GRX [2Fe–2S] clusters form complexes with BOLA proteins, in which the [2Fe–2S] cluster is ligated using the GRX conserved Cys, a Cys from GSH, and His or Cys residues on the BOLA protein
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A few studies have failed to show such OS changes in dogs with cardiac conditions, possibly due to the specific biomarkers studied, non-linear changes in oxidation across stages of MMVD or DCM, or potential antioxidant effects of some therapeutic agents such as benazepril or sildenafil, which have yet to be conclusively studied [32,39,42]
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