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Inflammation in NASH is associated with the exacerbated production of inflammatory factors originated from both extrahepatic sites (e.g., adipose tissue, gut) or, within the liver, with the activation of Kupffer cells and by hepatocytes themselves, as a secondary consequence of the hepatic lipotoxic attack [23, 141] (Fig

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Proceedings of the national academy of Sciences, Proinflammatory T-cell responses gut microbiota promote Exp