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In a 12-week facial-cream study led by James Leyden in 71 women with photoaged skin, twice-daily use improved density, firmness, clarity, and laxity, reduced fine lines and wrinkle depth, and lightened mottled pigmentation versus control.17 In a comparison, aesthetic dermatologists still cite that a copper-peptide cream raised collagen in roughly 70% of subjects, against about 50% for vitamin C and 40% for retinoic acid—rare company for any ingredient that beats a retinoid on collagen.18 Later work using nanocarrier delivery reported real reductions in wrinkle volume and depth, and confirmed that GHK-Cu boosts collagen and elastin in fibroblasts at concentrations as low as 0.01 nanomolar