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Low glutathione measured within red blood cells is an important indicator of the body's ability to defend itself against oxidative stress. Because red blood cells are constantly exposed to oxygen and free

This conception has dominated nutritional and therapeutic recommendations for decades, leading to the broad, prophylactic use of antioxidant supplements in the general population without regard for individual redox status or the nuanced physiological roles of ROS as signaling molecules

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But a small percentage require medical evaluation