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Additionally, CerS6 interacts with the sequestosome 1 protein, impairing mitophagy and contributing to mitochondrial dysfunction (Xu et al., 2024)

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7,8,458,459 These factors are classified into regulatory modules—metabolic, immune/inflammatory, stress-responsive, and oncogenic—to emphasize how they converge on autophagy-related signaling axes such as the mTOR–AMPK, TFEB–CLEAR, and p62–Keap1–Nrf2 loops