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This positions the Sesn2–PINK1–Parkin axis as an attractive pharmacological entry point to restore integrated mitochondria–lysosome quality control, promote clearance of damaged mitochondria, reduce mtROS and DAMP release, and secondarily limit NLRP3 inflammasome activation and ER stress
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4) Pharmacokinetics & Safety (Preclinical) In animals, intravenous and intramuscular dosing provide systemic exposure with a relatively short elimination half-life
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